摘 要：目的 探讨SPECT/CT双时相 99mTc-MIBI断层显像在乳腺癌临床中的诊断价值。 方法 选取2015 年 1 月～2017 年 5月广西柳州市中医院胸外科收治的女性乳腺疾病患者 98 例进行了术前两种检查方法的诊断，并将诊断结果记录，与术后的病理结果进行比对。结果 SPECT/CT双时相 99mTc-MIBI断层显像的敏感性94.80%、特异性90.00%、准确性93.90%，高于钼靶 X 线检查的敏感性82.10%、特异性60.00%、准确性77.60%，SPECT/CT双时相 99mTc-MIBI断层显像和钼靶 X 线检查对腋窝淋巴结转移灶的检出率分别为84.30%和59.40%，两种检查方法对乳腺癌的诊断比较均有统计学差异（P<0.05）。 结论 99mTc- MIBI双时相断层显像对乳腺癌的诊断效能优于钼靶X线检查，有较高的实用价值。
关键词：乳腺癌;SPECT/CT;99mTc-MIBI断层显像;钼靶 X 线
中图分类号：R817.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.05.053
文章编号：1006-1959（2018）05-0147-03
Application of SPECT/CT Dual-phase 99mTc-MIBI Tomography in the Diagnosis of Breast Cancer
DONG Yun
（Department of Nuclear Medicine，Liuzhou Chinese Medicine Hospital，Liuzhou 545001，Guangxi，China）
Abstract：Objective To evaluate the diagnostic value of SPECT/CT dual-phase 99mTc-MIBI tomography in breast cancer.Methods A total of 98 women with breast diseases admitted in Department of thoracic surgery，Liuzhou Hospital of traditional Chinese medicine in January 2015～2017 May，were selected for the diagnosis of two kinds of examination methods before operation，and the diagnosis results were compared with postoperative pathological results.The results of the two diagnostic methods were compared.Results SPECT/CT 99mTc-MIBI double phase imaging sensitivity of 94.80%，specificity of 90.00%，accuracy of 93.90%，higher than mammography sensitivity 82.10%，specificity 60.00%，accuracy 77.60%，SPECT/CT 99mTc-MIBI double phase imaging and mammography node metastasis detection rates were 84.30% and 59.40% of axillary lymph，two methods in diagnosis of breast cancer were statistically significant（P<0.05）.Conclusion 99mTc- MIBI double phase tomography is superior to mammography in diagnosis of breast cancer， and has high practical value.
Key words：Breast cancer;SPECT/CT;99mTc-MIBI tomography;Molybdenum target X-ray
乳腺癌（breast cancer）是婦女最常见的恶性肿瘤之一， 近年来发病率呈明显上升趋势[1]，早期诊断对乳腺癌尤其是有腋窝淋巴结转移者的手术治疗方案及预后起到至关重要的作用。一般由体检或彩超发现乳房可疑结节、肿块后大多都要进一步做乳腺钼靶X线检查。然而，乳腺钼靶X线检查对乳腺癌的阳性预测值较低，对于合并腋窝淋巴结转移者无法做出特异性判断[2]。因此，选择一种改进的非创伤性的技术检查乳腺病变，提高其与病理诊断的符合率，具有重要临床意义。本文对我院胸外科的98例乳腺肿块患者的术前乳腺钼靶X线检查和99mTc- MIBI双时相断层显像和术后病理检查进行了回顾性对比分析， 旨在探讨SPECT/CT双时相 99mTc-MIBI断层显像在乳腺癌临床中的诊断价值。
